Triazolo[4,3-a]pyridin-3(2H)-ones

ABSTRACT

Triazolo[4,3-a]pyridin-3-(2H)-one derivatives containing a 4-(optionally substituted phenyl)piperazinyl component attached to the two position of the triazolo-[4,3-a]pyridine component via a divalent radical such as --(CH 2 ) 5  --, --(CH 2 ) 6  --, --CH 3  CH(CH 3 )CH 2  --, --CH 2  C(CH 3 ) 2  CH 2  --, --CH 2  CH═CHCH 2  --, --CH 2  C.tbd.CCH 2  --, --CH 2  CH 2  OCH 2  CH 2  -- or a divalent cycloalkylene radical of 3 to 6 carbon atoms are disclosed. The compounds are useful in that they exhibit central nervous system pharmacological properties in standard laboratory tests considered predictive of analgetics, anti-psychotic (neuroleptics), antidepressant and antianxiety utility. Examples of specific embodiments of the invention are compounds having the formula 
     
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      ##STR1##                                                                 
Y                 R                                                       
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 ##STR2##         3-Cl                                                    
 ##STR3##         H                                                       
 ##STR4##         3-Cl                                                    
 ##STR5##         3-CF 3                                               
 ##STR6##         4-F                                                     
CH 2  CHCHCH 2                                                      
                  3-Cl                                                    
CH 2  CCCH 2                                                        
                  3-Cl                                                    
(CH 2 ) 5   3-Cl                                                    
(CH 2 ) 5   4-CH 3  O                                            
(CH 2 ) 5   2-CH 3                                               
(CH 2 ) 6   3-Cl                                                    
CH 2  C(CH 3 ) 2  CH 2                                        
                  3-Cl                                                    
CH 2  CH(CH 3 )CH 2                                              
                  3-CF 3                                               
CH 2  CH 2  OCH 2  CH 2                                       
                  3-Cl                                                    
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